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Science-backed writing on focus, nootropics, sleep, and cognitive performance, from the physicians and scientists at Roon.
Editors’ selection
The first results from our self-experimentation are in. One formulation did something unexpected: it eliminated ALL attention lapses and false alarms while achieving the fastest reaction times.
Everyone understands the concept of a "Limitless pill" vaguely. But surprisingly, there represents no single resource that actually specifies what that would mean. Here is our full specification for the ideal daily nootropic.
Nicotine pouches work for focus but trap you in addiction. We explore the Zyn problem and the third option we are building at Roon.
Recent dispatches
Caloric restriction mimetics like spermidine and resveratrol mimic fasting in the brain. Here's what the science actually supports—and what's overhyped.
Discover the 145-year methylene blue history—from textile dye to the first synthetic drug, and now a promising compound for memory and brain health.
High choline intake raises TMAO, a compound linked to heart disease and clotting. Learn the safe intake range and why megadosing choline backfires.
Can you stack adaptogens with caffeine? Learn what the research actually supports, which adaptogens pair best, and how to avoid wasting your money.
Panax ginseng vs rhodiola—which adaptogen actually boosts mental energy? See what the research says about cognitive performance, fatigue, and dosing.
Sulbutiamine vs caffeine compared: how they work, what the evidence says, and which is better for focus, energy, and motivation. Make an informed choice.
Honokiol and apigenin both target GABA-A receptors, but work differently. Compare their binding, effects, and which suits sleep vs. daytime calm.
The Ratamess study tested synephrine and caffeine on squat performance. See what the data actually shows about reps, power, and effort—without the hype.
Discover how NMN affects brain blood flow by restoring neurovascular coupling in aging brains. Breaking down the key 2019 University of Oklahoma study.
Discover the landmark lemon balm stress study that revealed dose-dependent effects on calm and cognition. What 300mg vs 600mg actually did in lab trials.
A single 25mg dose of Zembrin quieted amygdala reactivity in MRI scans. Here's what the zembrin amygdala study really showed—and where the hype falls
The affron saffron study tested 28mg of saffron extract on healthy adults with low mood. See what a 4-week trial found on validated mood scales.
The blueberry memory study by Krikorian (2010) was the first human trial linking blueberry juice to improved recall. Here's what the data actually shows.
Discover how orexin controls wakefulness, why losing it causes narcolepsy, and how new sleep drugs target this powerful brain system.
Discover how AMPA receptor nootropics (ampakines) work, what the science really shows, and why the gap between biology and brain supplements matters.
Discover how the glycine NMDA receptor relationship works as a coincidence detector driving learning and long-term potentiation in the brain.
Senolytics may protect the aging brain by clearing zombie cells. See what mouse studies and human trials actually show before buying the supplements.
Your brain hoards vitamin C at 10x blood levels—here's why. Discover how ascorbate supports neurotransmitters, fights oxidative stress, and affects
Phenylethylamine triggers dopamine and euphoria—but vanishes in minutes. Learn why PEA supplements rarely work and what the science actually says.
Semax and selank promise sharper focus and less anxiety. But what does the evidence actually support? An honest look at the research, gaps, and risks.
Discover how thiamine (B1) converts glucose into brain fuel, why low B1 causes brain fog, and who's at risk for thiamine deficiency affecting cognition.
Octopamine appears on fat-burner labels, but human evidence is nearly nonexistent. Learn what the science actually says before you buy.
Fasoracetam is the only racetam studied in a real ADHD clinical trial. Learn what the evidence shows, who it may help, and its legal status.
Pramiracetam boosts choline uptake harder than most racetams. Learn how it works, optimal dosing, and why skipping choline is a mistake.